46th Street Station may refer to:
- 46th Street (IND Queens Boulevard Line) in Queens, New York City
- 46th Street–Bliss Street (IRT Flushing Line) in Queens, New York City
- 46th Street (BMT Fifth Avenue Line), a demolished station in Brooklyn, New York City
- 46th Street station (Philadelphia), a SEPTA station in Philadelphia
- Several METRO stations in Minneapolis, Minnesota