58th Regiment or 58th Infantry Regiment may refer to:
- 58th Regiment of Foot (disambiguation), three British Army units have carried this name
- 58th (Middlesex) Searchlight Regiment, Royal Artillery, a British Army unit, 1938–1955
- 58th Vaughan's Rifles (Frontier Force), a unit of the British Indian Army
- 58th Infantry Regiment (United States), most recent 58th Infantry in the United States Army
- American Civil War
- Union (Northern) Army
- Confederate (Southern) Army