60S ribosomal protein L13a

60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.

RPL13A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL13A, L13A, TSTA1, ribosomal protein L13a
External IDs	MGI: 1351455; HomoloGene: 111053; GeneCards: RPL13A; OMA:RPL13A - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 49,487,510 bp End 49,493,057 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 29.14 cM Start 44,774,982 bp End 44,778,185 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary right uterine tube canal of the cervix skin of abdomen ganglionic eminence skin of leg ectocervix right lobe of thyroid gland body of uterus Top expressed in ventricular zone urinary bladder yolk sac ganglionic eminence lip ovary thymus adrenal gland neural layer of retina spleen More reference expression data BioGPS n/a
Gene ontology Molecular function mRNA binding RNA binding structural constituent of ribosome Cellular component cytoplasm cytosol ribosome membrane focal adhesion large ribosomal subunit nucleolus GAIT complex cytosolic large ribosomal subunit nucleus ribonucleoprotein complex Biological process negative regulation of translation viral transcription SRP-dependent cotranslational protein targeting to membrane negative regulation of formation of translation preinitiation complex cellular response to interferon-gamma translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23521 22121 Ensembl ENSG00000142541 ENSMUSG00000074129 UniProt P40429 P19253 RefSeq (mRNA) NM_001270491 NM_012423 NM_009438 RefSeq (protein) NP_001257420 NP_036555 NP_033464 Location (UCSC) Chr 19: 49.49 – 49.49 Mb Chr 7: 44.77 – 44.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative polyA signals have been observed. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in its second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID 8722009.
• Price SR, Nightingale MS, Bobak DA, et al. (1993). "Conservation of a 23-kDa human transplantation antigen in mammalian species". Genomics. 14 (4): 959–964. doi:10.1016/S0888-7543(05)80117-X. PMID 1282492.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J. Mol. Biol. 260 (2): 178–195. doi:10.1006/jmbi.1996.0391. PMID 8764399.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Higa S, Yoshihama M, Tanaka T, Kenmochi N (2000). "Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome". Gene. 240 (2): 371–377. doi:10.1016/S0378-1119(99)00429-1. PMID 10580157. S2CID 25643638.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–258. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
• Mazumder B, Sampath P, Seshadri V, et al. (2003). "Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control" (PDF). Cell. 115 (2): 187–198. doi:10.1016/S0092-8674(03)00773-6. PMID 14567916. S2CID 14209529.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.