60S ribosomal protein L19

Large ribosomal subunit protein eL19 is a protein that in humans is encoded by the RPL19 gene.

RPL19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4UJE, 4UJD, 4D67, 4V5Z, 4UJC, 4D5Y
Identifiers
Aliases	RPL19, L19, ribosomal protein L19
External IDs	OMIM: 180466; MGI: 98020; HomoloGene: 68105; GeneCards: RPL19; OMA:RPL19 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 39,200,283 bp End 39,204,840 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 97,917,536 bp End 97,921,318 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad Achilles tendon granulocyte lymph node skin of thigh left ovary skin of hip canal of the cervix right ovary olfactory zone of nasal mucosa Top expressed in epiblast embryo embryo ventricular zone thymus urinary bladder uterus blastocyst adrenal gland ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding large ribosomal subunit rRNA binding 5.8S rRNA binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytosolic large ribosomal subunit polysomal ribosome Biological process protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cytoplasmic translation liver regeneration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6143 19921 Ensembl ENSG00000108298 ENSMUSG00000017404 UniProt P84098 P84099 RefSeq (mRNA) NM_000981 NM_001330200 NM_001159483 NM_009078 RefSeq (protein) NP_000972 NP_001317129 NP_001152955 NP_033104 Location (UCSC) Chr 17: 39.2 – 39.2 Mb Chr 11: 97.92 – 97.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Pseudogenes

There are 21 pseudogenes: RPL19P1, RPL19P2, RPL19P3, RPL19P4, RPL19P5, RPL19P6, RPL19P7, RPL19P8, RPL19P9, RPL19P10, RPL19P11, RPL19P12, RPL19P13, RPL19P14, RPL19P15, RPL19P16, RPL19P17, RPL19P18, RPL19P19, RPL19P20, and RPL19P21.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kumabe T, Sohma Y, Yamamoto T (1992). "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19". Nucleic Acids Res. 20 (10): 2598. doi:10.1093/nar/20.10.2598. PMC 312399. PMID 1598220.
• Chan YL, Lin A, McNally J, et al. (1987). "The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein". J. Biol. Chem. 262 (3): 1111–5. doi:10.1016/S0021-9258(19)75757-3. PMID 3542997.
• Davies B, Fried M (1995). "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region". Genomics. 25 (2): 372–80. doi:10.1016/0888-7543(95)80036-L. PMID 7789970.
• Henry JL, Coggin DL, King CR (1993). "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2". Cancer Res. 53 (6): 1403–8. PMID 8095182.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Deprez PH, Sempoux C, De Saeger C, et al. (2002). "Expression of cholecystokinin in the duodenum of patients with coeliac disease: respective role of atrophy and lymphocytic infiltration". Clin. Sci. 103 (2): 171–7. doi:10.1042/CS20020033. PMID 12149109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bee A, Ke Y, Forootan S, et al. (2006). "Ribosomal protein l19 is a prognostic marker for human prostate cancer". Clin. Cancer Res. 12 (7 Pt 1): 2061–5. doi:10.1158/1078-0432.CCR-05-2445. PMID 16609016. S2CID 7231453.
• Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis". BMC Genomics. 8: 26. doi:10.1186/1471-2164-8-26. PMC 1796866. PMID 17244347.