60S ribosomal protein L23a

Large ribosomal subunit protein uL23 is a protein that in humans is encoded by the RPL23A gene.

RPL23A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL23A, L23A, MDA20, ribosomal protein L23a
External IDs	OMIM: 602326; MGI: 3040672; HomoloGene: 133569; GeneCards: RPL23A; OMA:RPL23A - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 28,719,985 bp End 28,724,359 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 78,071,758 bp End 78,074,410 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary Achilles tendon canal of the cervix right ovary right uterine tube ectocervix pituitary gland skin of abdomen body of uterus skin of leg Top expressed in ovary epiblast ganglionic eminence thymus ventricular zone uterus embryo adrenal gland lip blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding structural constituent of ribosome protein binding cadherin binding RNA binding TORC2 complex binding large ribosomal subunit rRNA binding Cellular component cytoplasm cytosol ribosome intracellular anatomical structure nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus TORC2 complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit assembly translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cell population proliferation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6147 268449 Ensembl ENSG00000198242 ENSMUSG00000058546 UniProt P62750 P62751 RefSeq (mRNA) NM_000984 NM_207523 RefSeq (protein) NP_000975 NP_997406 Location (UCSC) Chr 17: 28.72 – 28.72 Mb Chr 11: 78.07 – 78.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 rRNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL23 family. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Clinical significance

L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients.

Pseudogenes

95 related pseudogenes are known, with symbols RPL23AP1 - RPL23AP97, excluding RPL23AP9 and RPL23AP13.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Fan W, Cai W, Parimoo S, Schwarz DC, Lennon GG, Weissman SM (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070. S2CID 21628804.
• Jiang H, Lin JJ, Tao J, Fisher PB (1997). "Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta". Oncogene. 14 (4): 473–80. doi:10.1038/sj.onc.1200858. PMID 9053844.
• Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
• Rogan S, Heaphy S (2001). "The vaccinia virus E3L protein interacts with SUMO-1 and ribosomal protein L23a in a yeast two hybrid assay". Virus Genes. 21 (3): 193–5. doi:10.1023/A:1008139514123. PMID 11129635. S2CID 8941317.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a