60S ribosomal protein L37a

60S ribosomal protein L37a is a protein that in humans is encoded by the RPL37A gene.

RPL37A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J92, 4UJE, 4UJD, 4D67, 4V5Z, 4UJC, 4D5Y
Identifiers
Aliases	RPL37A, L37A, ribosomal protein L37a
External IDs	OMIM: 613314; MGI: 98068; HomoloGene: 47964; GeneCards: RPL37A; OMA:RPL37A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 216,498,825 bp End 216,579,180 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C3 Start 72,750,449 bp End 72,752,972 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh lactiferous duct cerebellar vermis caput epididymis parietal pleura nipple endothelial cell superficial temporal artery pericardium visceral pleura Top expressed in yolk sac embryo blastocyst embryo morula ventricular zone lip dentate gyrus of hippocampal formation granule cell superior frontal gyrus entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome metal ion binding protein binding RNA binding Cellular component cytosol ribosome focal adhesion intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome nucleus Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6168 19981 Ensembl ENSG00000197756 ENSMUSG00000046330 UniProt P61513 P61514 RefSeq (mRNA) NM_000998 NM_009084 RefSeq (protein) NP_000989 NP_033110 Location (UCSC) Chr 2: 216.5 – 216.58 Mb Chr 1: 72.75 – 72.75 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Saha DP, Tirumalai PS, Scala LA, Howells RD (1993). "Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines". Gene. 132 (2): 285–9. doi:10.1016/0378-1119(93)90209-L. PMID 8224875.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: P61513 (Human 60S ribosomal protein L37a) at the PDBe-KB.