The 6A RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] 6A motifs are found in Actinomycetota, Bacillota, and Fusobacteriota. 6A RNAs likely function in trans as sRNAs, and contain a pseudoknot.
| 6A | |
|---|---|
 Consensus secondary structure and sequence conservation of 6A RNA | |
| Identifiers | |
| Symbol | 6A |
| Rfam | RF02925 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The 6A RNA motif was named after 6 A (adenosine) nucleotides that are highly conserved in the structure. No other nucleotides are highly conserved. Many 6A RNAs occur adjacent to other 6A RNAs, although no hypothesis to explain this phenomenon has been proposed.
References
edit- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.