7-dimethylallyltryptophan synthase (EC 2.5.1.80, 7-DMATS) is an enzyme with systematic name dimethylallyl-diphosphate:L-tryptophan 7-dimethylallyltransferase.[1][2] This enzyme catalyses the following chemical reaction:
| 7-dimethylallyltryptophan synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.80 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- dimethylallyl diphosphate + L-tryptophan diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase).
References
edit- ^ Kremer A, Li SM (July 2008). "Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives". Applied Microbiology and Biotechnology. 79 (6): 951–61. doi:10.1007/s00253-008-1505-3. PMID 18481055.
- ^ Kremer A, Westrich L, Li SM (October 2007). "A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction, purification and biochemical characterization". Microbiology. 153 (Pt 10): 3409–16. doi:10.1099/mic.0.2007/009019-0. PMID 17906140.
External links
edit- 7-dimethylallyltryptophan+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
