The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.
The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.[5] It is expressed in a wide range of human tissues.[6]
Function
editThe protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).[7]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000081760 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029482 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.
- ^ "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.
- ^ Aguiló F, Camarero N, Relat J, Marrero PF, Haro D (March 2010). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma" (PDF). The Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. PMID 20102333. S2CID 1043396.
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