The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.

AACS
Identifiers
AliasesAACS, ACSF1, SUR-5, acetoacetyl-CoA synthetase
External IDsOMIM: 614364; MGI: 1926144; HomoloGene: 11322; GeneCards: AACS; OMA:AACS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_023928
NM_001319839
NM_001319840

NM_030210

RefSeq (protein)

NP_001306768
NP_001306769
NP_076417

NP_084486

Location (UCSC)Chr 12: 125.07 – 125.14 MbChr 5: 125.55 – 125.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.[5] It is expressed in a wide range of human tissues.[6]

Function

edit

The protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081760Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029482Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.
  6. ^ "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.
  7. ^ Aguiló F, Camarero N, Relat J, Marrero PF, Haro D (March 2010). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma" (PDF). The Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. PMID 20102333. S2CID 1043396.