Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.[5][6][7]

ABCC12
Identifiers
AliasesABCC12, MRP9, ATP binding cassette subfamily C member 12
External IDsOMIM: 607041; MGI: 2441679; HomoloGene: 57211; GeneCards: ABCC12; OMA:ABCC12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145190
NM_033226
NM_145187
NM_145188
NM_145189

NM_172912

RefSeq (protein)

NP_150229

NP_766500

Location (UCSC)Chr 16: 48.08 – 48.16 MbChr 8: 87.21 – 87.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.[7] Loss of function is implicated in hereditary cholestasis.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140798Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036872Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. S2CID 9528197.
  6. ^ Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, et al. (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364.
  7. ^ a b "Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12".
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Adding link to ABCC12 gene details page and display in UCSC genome browser.

Further reading

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