ABRA (gene)

Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene. The mouse and rat homologues are known as STARS (striated muscle activator of Rho signalling) and MS1 (myocyte stress 1) respectively.

ABRA
Identifiers
Aliases	ABRA, STARS, actin binding Rho activating protein
External IDs	OMIM: 609747; MGI: 2444891; HomoloGene: 34713; GeneCards: ABRA; OMA:ABRA - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q23.1 Start 106,759,483 bp End 106,770,244 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 B3.1 Start 41,727,472 bp End 41,733,116 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii quadriceps femoris muscle vastus lateralis muscle deltoid muscle right ventricle muscle of thigh gastrocnemius muscle myocardium body of tongue Top expressed in interventricular septum muscle of thigh soleus muscle knee joint extraocular muscle quadriceps femoris muscle vastus lateralis muscle digastric muscle tibialis anterior muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding Cellular component cytoplasm plasma membrane sarcomere myofibril cytoskeleton actin cytoskeleton Biological process positive regulation of Rho protein signal transduction protein transport positive regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 137735 223513 Ensembl ENSG00000174429 ENSMUSG00000042895 UniProt Q8N0Z2 Q8BUZ1 RefSeq (mRNA) NM_139166 NM_175456 RefSeq (protein) NP_631905 NP_780665 Location (UCSC) Chr 8: 106.76 – 106.77 Mb Chr 15: 41.73 – 41.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

MS1/STARS is regulated by MyoD during myogenic differentiation of the C2C12 cell line.

External links

• Human ABRA genome location and ABRA gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kuwahara K, Barrientos T, Pipes GC, et al. (2005). "Muscle-specific signaling mechanism that links actin dynamics to serum response factor". Mol. Cell. Biol. 25 (8): 3173–81. doi:10.1128/MCB.25.8.3173-3181.2005. PMC 1069631. PMID 15798203.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kuwahara K, Teg Pipes GC, McAnally J, et al. (2007). "Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity". J. Clin. Invest. 117 (5): 1324–34. doi:10.1172/JCI31240. PMC 1838928. PMID 17415416.