Acetate—[acyl-carrier protein] ligase (EC 6.2.1.35, HS-acyl-carrier protein:acetate ligase, [acyl-carrier protein]:acetate ligase, MadH) is an enzyme with systematic name acetate:(acyl-carrier-protein) ligase (AMP-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
| Acetate—[acyl-carrier protein] ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.2.1.35 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ATP + acetate + an [acyl-carrier protein] AMP + diphosphate + an acetyl-[acyl-carrier protein]
This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase.
References
edit- ^ Hilbi H, Dehning I, Schink B, Dimroth P (July 1992). "Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme" (PDF). European Journal of Biochemistry. 207 (1): 117–23. doi:10.1111/j.1432-1033.1992.tb17028.x. PMID 1628643.
- ^ Berg M, Hilbi H, Dimroth P (April 1996). "The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group". Biochemistry. 35 (15): 4689–96. doi:10.1021/bi952873p. PMID 8664258.
- ^ Berg M, Hilbi H, Dimroth P (April 1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function". European Journal of Biochemistry. 245 (1): 103–15. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
- ^ Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.
External links
edit- ACP-SH:acetate+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
