Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.[5][6][7]

ACSBG1
Identifiers
AliasesACSBG1, BG, BG1, BGM, GR-LACS, LPD, acyl-CoA synthetase bubblegum family member 1
External IDsOMIM: 614362; MGI: 2385656; HomoloGene: 9044; GeneCards: ACSBG1; OMA:ACSBG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199377
NM_015162

NM_053178

RefSeq (protein)

NP_001186306
NP_055977

NP_444408

Location (UCSC)Chr 15: 78.17 – 78.25 MbChr 9: 54.51 – 54.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis.[7] The conversion of long chain fatty acids into long chain acyl-CoAs in mice is catalysed by ACSBG1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103740Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032281Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.
  7. ^ a b "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".
  8. ^ Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
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Further reading

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