ADAMTS12

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.

ADAMTS12
Identifiers
Aliases	ADAMTS12, PRO4389, ADAM metallopeptidase with thrombospondin type 1 motif 12
External IDs	OMIM: 606184; MGI: 2146046; HomoloGene: 12808; GeneCards: ADAMTS12; OMA:ADAMTS12 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5p13.3-p13.2 Start 33,523,535 bp End 33,892,019 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 A1 Start 11,064,790 bp End 11,349,231 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle stromal cell of endometrium visceral pleura gonad islet of Langerhans adipose tissue subcutaneous adipose tissue sural nerve abdominal fat parietal pleura Top expressed in dermis stroma of bone marrow calvaria efferent ductule vestibular sensory epithelium mammary gland external carotid artery aortic valve internal carotid artery otolith organ More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding peptidase activity protein binding metalloendopeptidase activity hydrolase activity metallopeptidase activity zinc ion binding Cellular component extracellular region extracellular matrix collagen-containing extracellular matrix Biological process regulation of endothelial tube morphogenesis proteoglycan catabolic process negative regulation of hepatocyte growth factor receptor signaling pathway negative regulation of cellular response to vascular endothelial growth factor stimulus cellular response to tumor necrosis factor cellular response to BMP stimulus negative regulation of cellular response to hepatocyte growth factor stimulus proteolysis negative regulation of chondrocyte differentiation cellular response to interleukin-1 regulation of inflammatory response proteolysis involved in cellular protein catabolic process cell-matrix adhesion cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81792 239337 Ensembl ENSG00000151388 ENSG00000281690 ENSMUSG00000047497 UniProt P58397 Q811B3 RefSeq (mRNA) NM_030955 NM_001324511 NM_001324512 NM_175501 RefSeq (protein) NP_001311440 NP_001311441 NP_112217 NP_780710 Location (UCSC) Chr 5: 33.52 – 33.89 Mb Chr 15: 11.06 – 11.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.

Further reading

• Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases". Int. J. Biochem. Cell Biol. 33 (1): 33–44. doi:10.1016/S1357-2725(00)00061-3. PMID 11167130.
• Llamazares M, Obaya AJ, Moncada-Pazos A, et al. (2008). "The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway". J. Cell Sci. 120 (Pt 20): 3544–52. doi:10.1242/jcs.005751. hdl:10651/42564. PMID 17895370.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Liu CJ, Kong W, Xu K, et al. (2006). "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein". J. Biol. Chem. 281 (23): 15800–8. doi:10.1074/jbc.M513433200. PMC 1483932. PMID 16611630.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.237
• Human ADAMTS12 genome location and ADAMTS12 gene details page in the UCSC Genome Browser.