ADAMTS14 encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Mature enzyme is generated by the proteolytically process of the encoded preproprotein. The enzyme cleaves the amino-propeptides of fibrillar collagens, enabling collagen fibril formation prior to assembly of collagen, which is a major extracellular matrix (ECM) protein.[1][2]
References
edit- ^ "ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-19.
This article incorporates text from this source, which is in the public domain.
- ^ "ADAMTS14 Gene - GeneCards | ATS14 Protein | ATS14 Antibody". www.genecards.org. Retrieved 2022-05-19.
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