ADAMTSL4

ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.

ADAMTSL4
Identifiers
Aliases	ADAMTSL4, ADAMTSL-4, ECTOL2, TSRC1, ADAMTS like 4
External IDs	OMIM: 610113; MGI: 2389008; HomoloGene: 23141; GeneCards: ADAMTSL4; OMA:ADAMTSL4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.2 Start 150,549,369 bp End 150,560,937 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 95,583,511 bp End 95,595,228 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua gastric mucosa tibial nerve left uterine tube muscle of thigh apex of heart upper lobe of left lung canal of the cervix Descending thoracic aorta body of uterus Top expressed in interventricular septum extraocular muscle muscle of thigh lip myocardium of ventricle ankle sciatic nerve right ventricle temporal muscle cardiac muscles More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding peptidase activity protein binding Cellular component extracellular region interstitial matrix endoplasmic reticulum lumen cellular component extracellular matrix collagen-containing extracellular matrix Biological process positive regulation of apoptotic process extracellular matrix organization proteolysis apoptotic process epithelial cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54507 229595 Ensembl ENSG00000143382 ENSMUSG00000015850 UniProt Q6UY14 Q80T21 RefSeq (mRNA) NM_001288607 NM_001288608 NM_019032 NM_025008 NM_001378596 NM_001301705 NM_144899 RefSeq (protein) NP_001275536 NP_001275537 NP_061905 NP_079284 NP_001365525 NP_001288634 NP_659148 Location (UCSC) Chr 1: 150.55 – 150.56 Mb Chr 3: 95.58 – 95.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Adams JC, Tucker RP (Jun 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Developmental Dynamics. 218 (2): 280–299. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–15729. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Liu J, Guo Q, Chen B, Yu Y, Lu H, Li YY (Jan 2006). "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90". FEBS Letters. 580 (1): 245–250. doi:10.1016/j.febslet.2005.12.005. PMID 16364318. S2CID 8768006.

External links

• GeneReviews/NCBI/NIH/UW entry on ADAMTSL4-Related Eye Disorders, Autosomal Recessive Isolated Ectopia Lentis, Ectopia Lentis et Pupillae
• Human ADAMTSL4 genome location and ADAMTSL4 gene details page in the UCSC Genome Browser.