Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene .[ 5]
ADCY10 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CLK , 4CLL , 4CLP , 4CLS , 4CLT , 4CLU , 4CLW , 4CLY , 4CLZ , 4CM0 , 4CM2 , 4OYA , 4OYB , 4OYI , 4OYM , 4OYO , 4OYP , 4OYW , 4OYX , 4OYZ , 4OZ2 , 4OZ3 , 4UST , 4USU , 4USV , 4USW , 5D0R
Identifiers Aliases ADCY10 External IDs OMIM : 605205 ; MGI : 2660854 ; HomoloGene : 10188 ; GeneCards : ADCY10 ; OMA :ADCY10 - orthologs Wikidata
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa , implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.[ 6]
Clinical significance
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^ a b c GRCh38: Ensembl release 89: ENSG00000143199 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026567 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Reed BY, Heller HJ, Gitomer WL, Pak CY (November 1999). "Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24" . The Journal of Clinical Endocrinology and Metabolism . 84 (11): 3907–3913. doi :10.1210/jcem.84.11.6155 PMID 10566627 . ^ "Entrez Gene: ADCY10" .^ Akbari A, Pipitone GB, Anvar Z, Jaafarinia M, Ferrari M, Carrera P, et al. (June 2019). "ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria". Human Reproduction . 34 (6): 1155–1164. doi :10.1093/humrep/dez048 . PMID 31119281 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
