ADH7

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.

ADH7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AGN, 1D1S, 1D1T
Identifiers
Aliases	ADH7, ADH4, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
External IDs	OMIM: 600086; MGI: 87926; HomoloGene: 37333; GeneCards: ADH7; OMA:ADH7 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q23 Start 99,412,261 bp End 99,435,510 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 G3|3 64.13 cM Start 137,923,521 bp End 137,939,143 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa oral cavity nasal epithelium epithelium of nasopharynx mucosa of pharynx mucosa of paranasal sinus gums gingival epithelium testicle palpebral conjunctiva Top expressed in esophagus superior surface of tongue gastric mucosa mucous cell of stomach epithelium of stomach pyloric antrum transitional epithelium of urinary bladder lip corneal stroma conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aldehyde oxidase activity zinc ion binding metal ion binding NAD-retinol dehydrogenase activity ethanol binding retinol binding oxidoreductase activity receptor antagonist activity alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase activity, zinc-dependent Cellular component cytoplasm intracellular anatomical structure extracellular region cytosol plasma membrane Biological process ethanol catabolic process response to bacterium retinol metabolic process retinoic acid metabolic process fatty acid omega-oxidation retinoid metabolic process response to ethanol ethanol oxidation extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131 11529 Ensembl ENSG00000196344 ENSMUSG00000055301 UniProt P40394 Q64437 RefSeq (mRNA) NM_001166504 NM_000673 NM_009626 RefSeq (protein) NP_000664 NP_001159976 NP_033756 Location (UCSC) Chr 4: 99.41 – 99.44 Mb Chr 3: 137.92 – 137.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.

Further reading

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD (Jul 1997). "X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity". The Journal of Biological Chemistry. 272 (30): 18558–63. doi:10.1074/jbc.272.30.18558. PMID 9228021.
• Yokoyama H, Baraona E, Lieber CS (Jan 1996). "Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH". Genomics. 31 (2): 243–5. doi:10.1006/geno.1996.0040. PMID 8824810.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Yokoyama S, Matsuo Y, Ramsbotham R, Yokoyama R (Sep 1994). "Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7)". FEBS Letters. 351 (3): 411–5. doi:10.1016/0014-5793(94)00895-7. PMID 8082805. S2CID 31829053.
• Yokoyama H, Baraona E, Lieber CS (Aug 1994). "Molecular cloning of human class IV alcohol dehydrogenase cDNA". Biochemical and Biophysical Research Communications. 203 (1): 219–24. doi:10.1006/bbrc.1994.2170. PMID 8074657.
• Farrés J, Moreno A, Crosas B, Peralba JM, Allali-Hassani A, Hjelmqvist L, Jörnvall H, Parés X (Sep 1994). "Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships". European Journal of Biochemistry. 224 (2): 549–57. doi:10.1111/j.1432-1033.1994.00549.x. PMID 7925371.
• Zgombić-Knight M, Foglio MH, Duester G (Mar 1995). "Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro". The Journal of Biological Chemistry. 270 (9): 4305–11. doi:10.1074/jbc.270.9.4305. PMID 7876191.
• Kedishvili NY, Bosron WF, Stone CL, Hurley TD, Peggs CF, Thomasson HR, Popov KM, Carr LG, Edenberg HJ, Li TK (Feb 1995). "Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes". The Journal of Biological Chemistry. 270 (8): 3625–30. doi:10.1074/jbc.270.8.3625. PMID 7876099.
• Cheung B, Anderson JK, Holmes RS, Beacham IR (Feb 1995). "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis". Alcoholism: Clinical and Experimental Research. 19 (1): 185–6. doi:10.1111/j.1530-0277.1995.tb01490.x. PMID 7771649.
• Parés X, Cederlund E, Moreno A, Saubi N, Höög JO, Jörnvall H (May 1992). "Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class". FEBS Letters. 303 (1): 69–72. doi:10.1016/0014-5793(92)80479-Z. PMID 1592118. S2CID 41630387.

External links

• Human ADH4 genome location and ADH4 gene details page in the UCSC Genome Browser.
• Human ADH7 genome location and ADH7 gene details page in the UCSC Genome Browser.