The human ADI1 gene encodes the enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.[4][5][6]

ADI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADI1, APL1, ARD, Fe-ARD, MTCBP1, Ni-ARD, SIPL, mtnD, HMFT1638, acireductone dioxygenase 1
External IDsOMIM: 613400; MGI: 2144929; HomoloGene: 75081; GeneCards: ADI1; OMA:ADI1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001306077
NM_018269

NM_134052

RefSeq (protein)

NP_001293006
NP_060739

NP_598813

Location (UCSC)n/aChr 12: 28.73 – 28.73 Mb
PubMed search[2][3]
Wikidata
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Function

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The enzyme belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization.

Clinical significance

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Diseases associated with ADI1 include Klebsiella, and refsum disease.

ADI1 is capable for supporting hepatitis C virus replication in an otherwise non-permissive cell line.[7] Mouse hepatoma cells coexpressing human CD81 and ADI1/Sip-L supported HCV infection and replication.[8] Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.[9][10]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020629Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Uekita T, Gotoh I, Kinoshita T, Itoh Y, Sato H, Shiomi T, Okada Y, Seiki M (Mar 2004). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors". J Biol Chem. 279 (13): 12734–43. doi:10.1074/jbc.M309957200. PMID 14718544.
  5. ^ Hirano W, Gotoh I, Uekita T, Seiki M (Jun 2005). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway". Genes Cells. 10 (6): 565–74. doi:10.1111/j.1365-2443.2005.00859.x. PMID 15938715. S2CID 25563839.
  6. ^ "Entrez Gene: ADI1 acireductone dioxygenase 1".
  7. ^ Yeh CT, Lai HY, Chen TC, Chu CM, Liaw YF (2001). "Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line". J. Virol. 75 (22): 11017–24. doi:10.1128/JVI.75.22.11017-11024.2001. PMC 114682. PMID 11602742.
  8. ^ Yeh CT, Lai HY, Yeh YJ, Cheng JC (2008). "Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L". Biochem Biophys Res Commun. 372 (1): 157–61. doi:10.1016/j.bbrc.2008.05.018. PMID 18474223.
  9. ^ Cheng JC, Yeh YJ, Pai LM, Chang ML, Yeh CT (2009). "293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection". J. Med. Virol. 81 (9): 1560–8. doi:10.1002/jmv.21495. PMID 19626614. S2CID 27972307.
  10. ^ Hwang DR, Lai HY, Chang ML, Hsu JT, Yeh CT (2005). "Emergence of mutation clusters in the HCV genome during sequential viral passages in Sip-L expressing cells". J Virol Methods. 129 (2): 170–7. doi:10.1016/j.jviromet.2005.05.026. PMID 16005986.
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Further reading

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