AGPAT5

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that is encoded by the AGPAT5 gene in humans.

AGPAT5
Identifiers
Aliases	AGPAT5, 1LPAATE, 1-acylglycerol-3-phosphate O-acyltransferase 5
External IDs	OMIM: 614796; MGI: 1196345; HomoloGene: 10153; GeneCards: AGPAT5; OMA:AGPAT5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p23.1 Start 6,708,642 bp End 6,761,503 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 A1.3|8 10.3 cM Start 18,896,293 bp End 18,941,377 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ventricular zone ganglionic eminence left testis right testis endometrium C1 segment Achilles tendon caudate nucleus islet of Langerhans Top expressed in triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle skin of external ear seminal vesicula endothelial cell of lymphatic vessel pineal gland umbilical cord decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein binding acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity Cellular component integral component of membrane nuclear envelope membrane endoplasmic reticulum membrane mitochondrial outer membrane mitochondrion endoplasmic reticulum nucleus Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process lipid metabolism hematopoietic progenitor cell differentiation phospholipid biosynthetic process metabolism acylglycerol metabolic process phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55326 52123 Ensembl ENSG00000155189 ENSG00000284980 ENSMUSG00000031467 UniProt Q9NUQ2 Q9D1E8 RefSeq (mRNA) NM_018361 NM_026792 RefSeq (protein) NP_060831 NP_081068 Location (UCSC) Chr 8: 6.71 – 6.76 Mb Chr 8: 18.9 – 18.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.

External links

• Human AGPAT5 genome location and AGPAT5 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lu B, Jiang YJ, Zhou Y, et al. (2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart". Biochem. J. 385 (Pt 2): 469–77. doi:10.1042/BJ20041348. PMC 1134718. PMID 15367102.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Agarwal AK, Barnes RI, Garg A (2006). "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity". Arch. Biochem. Biophys. 449 (1–2): 64–76. doi:10.1016/j.abb.2006.03.014. PMID 16620771.