Alpha-1,2-glucosyltransferase ALG10-A is an enzyme that in humans is encoded by the ALG10 gene.[5] It is a member of the Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase class of enzymes.
ALG10 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ALG10, ALG10A, DIE2, KCR1, alpha-1,2-glucosyltransferase, ALG10 alpha-1,2-glucosyltransferase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 618355; MGI: 2146159; HomoloGene: 6030; GeneCards: ALG10; OMA:ALG10 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
editThis gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.[6]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000139133 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075470 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ UniProt ID: Q5BKT4. Retrieved 30 November 2019
- ^ "Entrez Gene: ALG10 alpha-1,2-glucosyltransferase". Retrieved 30 November 2019.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.