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In enzymology, an AMP—thymidine kinase (EC 2.7.1.114) is an enzyme that catalyzes the chemical reaction
| AMP-thymidine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.114 | ||||||||
| CAS no. | 60440-28-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- AMP + thymidine adenosine + thymidine 5'-phosphate
Thus, the two substrates of this enzyme are AMP and thymidine, whereas its two products are adenosine and thymidine 5'-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is AMP:thymidine 5'-phosphotransferase. This enzyme is also called adenylate-nucleoside phosphotransferase.
References
edit- Falke D, Labenz J, Brauer D, Muller WE (1982). "Adenosine diphosphate: thymidine 5'-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase". Biochim. Biophys. Acta. 708 (1): 99–103. doi:10.1016/0167-4838(82)90207-2. PMID 6293576.
- Falke D, Nehrbass W, Brauer D, Muller WE (1981). "Adenylic acid: deoxythymidine 5'-phosphotransferase: evidence for the existence of a novel herpes simplex virus-induced enzyme". J. Gen. Virol. 53 (Pt 2): 247–55. doi:10.1099/0022-1317-53-2-247. PMID 6267178.
