ANKRD26

Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene. This protein has a function that is not currently understood.

ANKRD26
Identifiers
Aliases	ANKRD26, THC2, bA145E8.1, ankyrin repeat domain 26, ankyrin repeat domain containing 26
External IDs	OMIM: 610855; MGI: 1917887; HomoloGene: 45968; GeneCards: ANKRD26; OMA:ANKRD26 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.1 Start 26,973,793 bp End 27,100,494 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F1 Start 118,478,269 bp End 118,539,187 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Achilles tendon sural nerve gonad right uterine tube ventricular zone muscle of thigh right hemisphere of cerebellum anterior pituitary gastrocnemius muscle Top expressed in tail of embryo Rostral migratory stream ciliary body zygote genital tubercle secondary oocyte ventromedial nucleus neural layer of retina primary oocyte paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component centrosome Biological process negative regulation of fat cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22852 232339 Ensembl ENSG00000107890 ENSMUSG00000007827 UniProt Q9UPS8 Q811D2 RefSeq (mRNA) NM_001256053 NM_014915 NM_001081112 RefSeq (protein) NP_001242982 NP_055730 NP_001074581 Location (UCSC) Chr 10: 26.97 – 27.1 Mb Chr 6: 118.48 – 118.54 Mb PubMed search
Wikidata
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Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene.

Gene

ANKRD26 is found on chromosome 10, at 10q21. It has 6816 base pairs in the reference sequence mRNA transcript.

Neighborhood

LOC100289548 (PUTAETIVE UNCHARACTERIZED PROTEIN C10ORF52-LIKE) is located directly to the left (3') of ANKRD26, and is a protein coding gene located at 10p12.1. It has an unknown function. On the other side of LOC100289548 is NCRNA00202 non-protein coding RNA 202. On the 5' end of ANKRD26, YME1L1 can be found at 10q14.1. The protein encoded by the YME1-like 1 is an ortholog of yeast mitochondrial AAAmetalloprotease. This gene is thought to play a role in mitochondrial protein metabolism. On the positive strand of human chromosome ten, located next to the 5' end of ANKRD26 is MASTL, microtubule associated serine/threonine kinase-like. This particular gene encodes the microtubule associated serine/threonine kinase.1 Mutations within these gene have been expected to be associated with thrombocytopenia-2.

Protein

Ankyrin repeat domain-containing protein 26 has three conserved domains: ANK, SbcC, and DUF3496. ANK conserved domain is located from amino acid 74–199. Ankyrin repeats are found to mediate protein-protein interactions, and also contains two antiparallel helices, as well as a beta-hairpin. SbcC conserved domain can be found from amino acid 743–1333, and is domain associated with ATPase involved in DNA repair. There is also a domain of unknown function from amino acid 1538–1649.

Expression

In humans ANKRD26 was seen to be most highly expressed in the ear, lymph, esophagus, parathyroid, and placenta, as well as, most commonly seen in esophageal tumors and lymphoma, as well as seen in the blastocyst, fetus, juvenile, and adult developmental stages. In humans this is associated at all stages of life with lymphoma cancer as well as esophageal tumors. The association with expression in tissues and disease states doesn't show enough difference to link one another.

External links

• Human ANKRD26 genome location and ANKRD26 gene details page in the UCSC Genome Browser.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.