ANP32B

Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) also known as "acidic protein rich in leucines" (APRIL) is a protein that in humans is encoded by the ANP32B gene.

ANP32B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ELL, 2RR6
Identifiers
Aliases	ANP32B, APRIL, PHAPI2, SSP29, acidic nuclear phosphoprotein 32 family member B
External IDs	MGI: 1914878; HomoloGene: 21286; GeneCards: ANP32B; OMA:ANP32B - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.33 Start 97,983,341 bp End 98,015,943 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 46,450,902 bp End 46,472,657 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii trabecular bone optic nerve thymus internal globus pallidus corpus epididymis cartilage tissue dorsal motor nucleus of vagus nerve parotid gland caput epididymis Top expressed in tail of embryo genital tubercle zygote primary oocyte secondary oocyte bone marrow epiblast yolk sac ventricular zone thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding protein binding RNA polymerase binding Cellular component cytoplasm extracellular exosome nucleolus nucleus Biological process positive regulation of protein export from nucleus negative regulation of cell differentiation inner ear development nucleosome assembly roof of mouth development vasculature development activation of cysteine-type endopeptidase activity involved in apoptotic process ventricular system development histone exchange Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10541 67628 Ensembl ENSG00000136938 ENSMUSG00000028333 UniProt Q92688 Q9EST5 RefSeq (mRNA) NM_006401 NM_130889 RefSeq (protein) NP_006392 NP_570959 Location (UCSC) Chr 9: 97.98 – 98.02 Mb Chr 4: 46.45 – 46.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

APRIL is also the acronym used for an entirely different protein, TNFSF13, a member of the tumor necrosis factor superfamily whose alternative name, A PRoliferation Inducing Ligand, shares the same acronym as that for ANP32B

See also

• ANP32A, ANP32C, ANP32D, ANP32E

External links

• Human ANP32B genome location and ANP32B gene details page in the UCSC Genome Browser.

Further reading

• Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553. S2CID 39153579.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
• Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309. S2CID 43726887.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiang X, Kim HE, Shu H, et al. (2003). "Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway". Science. 299 (5604): 223–6. Bibcode:2003Sci...299..223J. doi:10.1126/science.1076807. PMID 12522243. S2CID 86628810.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.