APOBEC3F

DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.

APOBEC3F
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3WUS, 4IOU, 4J4J, 5HX5, 5HX4
Identifiers
Aliases	APOBEC3F, A3F, ARP8, BK150C2.4.MRNA, KA6, apolipoprotein B mRNA editing enzyme catalytic subunit 3F
External IDs	OMIM: 608993; HomoloGene: 105867; GeneCards: APOBEC3F; OMA:APOBEC3F - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 39,040,604 bp End 39,055,972 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen right ovary left ovary right uterine tube lymph node right adrenal gland left adrenal cortex right adrenal cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cytidine deaminase activity zinc ion binding metal ion binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines protein binding catalytic activity RNA binding hydrolase activity identical protein binding Cellular component cytoplasm P-body apolipoprotein B mRNA editing enzyme complex nucleus ribonucleoprotein complex Biological process negative regulation of transposition negative regulation of viral process immune system process base conversion or substitution editing negative regulation of viral genome replication defense response to virus DNA cytosine deamination DNA demethylation innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of defense response to virus by host cytidine deamination cytidine to uridine editing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200316 n/a Ensembl ENSG00000128394 n/a UniProt Q8IUX4 n/a RefSeq (mRNA) NM_001006666 NM_145298 n/a RefSeq (protein) NP_001006667 NP_660341 n/a Location (UCSC) Chr 22: 39.04 – 39.06 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.

References

Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. Zheng YH, Irwin D, Kurosu T, Tokunaga K, Sata T, Peterlin BM. J Virol. 2004 Jun;78(11):6073-6. doi: 10.1128/JVI.78.11.6073-6076.2004.

External links

• Human APOBEC3F genome location and APOBEC3F gene details page in the UCSC Genome Browser.

Further reading

• Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
• Franca R, Spadari S, Maga G (2006). "APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism". Med. Sci. Monit. 12 (5): RA92–8. PMID 16641889.
• Prashar Y, Weissman SM (1996). "Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 659–63. Bibcode:1996PNAS...93..659P. doi:10.1073/pnas.93.2.659. PMC 40108. PMID 8570611.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zheng YH, Irwin D, Kurosu T, et al. (2004). "Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication". J. Virol. 78 (11): 6073–6. doi:10.1128/JVI.78.11.6073-6076.2004. PMC 415831. PMID 15141007.
• Wiegand HL, Doehle BP, Bogerd HP, Cullen BR (2004). "A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins". EMBO J. 23 (12): 2451–8. doi:10.1038/sj.emboj.7600246. PMC 423288. PMID 15152192.
• Liddament MT, Brown WL, Schumacher AJ, Harris RS (2004). "APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo". Curr. Biol. 14 (15): 1385–91. doi:10.1016/j.cub.2004.06.050. PMID 15296757.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Haché G, Liddament MT, Harris RS (2005). "The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain". J. Biol. Chem. 280 (12): 10920–4. doi:10.1074/jbc.M500382200. PMID 15647250.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Zennou V, Bieniasz PD (2006). "Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates". Virology. 349 (1): 31–40. doi:10.1016/j.virol.2005.12.035. PMID 16460778.
• Tian C, Yu X, Zhang W, et al. (2006). "Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F". J. Virol. 80 (6): 3112–5. doi:10.1128/JVI.80.6.3112-3115.2006. PMC 1395459. PMID 16501124.
• Stenglein MD, Harris RS (2006). "APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism". J. Biol. Chem. 281 (25): 16837–41. doi:10.1074/jbc.M602367200. PMID 16648136.
• Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLOS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.