ARFGAP3

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

ARFGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRW
Identifiers
Aliases	ARFGAP3, ARFGAP1, ADP ribosylation factor GTPase activating protein 3
External IDs	OMIM: 612439; MGI: 1913501; HomoloGene: 134103; GeneCards: ARFGAP3; OMA:ARFGAP3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 42,796,502 bp End 42,858,106 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 83,183,940 bp End 83,234,448 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa parotid gland body of pancreas Achilles tendon tibia right adrenal cortex left adrenal gland left adrenal cortex cartilage tissue corpus epididymis Top expressed in lacrimal gland seminal vesicula salivary gland parotid gland islet of Langerhans submandibular gland spermatocyte transitional epithelium of urinary bladder duodenum spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component cytosol Golgi membrane Golgi apparatus membrane cytoplasm endoplasmic reticulum-Golgi intermediate compartment trans-Golgi network COPI vesicle coat Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intracellular protein transport vesicle-mediated transport protein secretion retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum positive regulation of GTPase activity transport COPI coating of Golgi vesicle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26286 66251 Ensembl ENSG00000242247 ENSMUSG00000054277 UniProt Q9NP61 Q9D8S3 RefSeq (mRNA) NM_001142293 NM_014570 NM_025445 NM_001357756 NM_001357757 RefSeq (protein) NP_001135765 NP_055385 NP_079721 NP_001344685 NP_001344686 Location (UCSC) Chr 22: 42.8 – 42.86 Mb Chr 15: 83.18 – 83.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.

External links

• Human ARFGAP1 genome location and ARFGAP1 gene details page in the UCSC Genome Browser.
• Human ARFGAP3 genome location and ARFGAP3 gene details page in the UCSC Genome Browser.

Further reading

• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.