ARID5B

AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.

ARID5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IG6, 2OEH
Identifiers
Aliases	ARID5B, DESRT, MRF-2, MRF2, AT-rich interaction domain 5B
External IDs	OMIM: 608538; MGI: 2175912; HomoloGene: 45872; GeneCards: ARID5B; OMA:ARID5B - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q21.2 Start 61,901,684 bp End 62,096,944 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B5.1- B5.2 Start 67,928,350 bp End 68,114,570 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell saphenous vein pericardium vena cava urethra parietal pleura decidua mucosa of urinary bladder lactiferous duct superficial temporal artery Top expressed in zygote left lung lobe stroma of bone marrow Paneth cell ciliary body secondary oocyte decidua ascending aorta ureter vas deferens More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription coactivator activity protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific histone demethylase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated liver development negative regulation of transcription, DNA-templated histone demethylation kidney development nitrogen compound metabolic process male gonad development female gonad development post-embryonic development fibroblast migration adrenal gland development multicellular organism growth fat cell differentiation platelet-derived growth factor receptor signaling pathway cell development muscle organ morphogenesis skeletal system morphogenesis positive regulation of DNA-binding transcription factor activity roof of mouth development face morphogenesis adipose tissue development fat pad development cellular response to leukemia inhibitory factor positive regulation of nucleic acid-templated transcription regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84159 71371 Ensembl ENSG00000150347 ENSMUSG00000019947 UniProt Q14865 Q8BM75 RefSeq (mRNA) NM_001244638 NM_032199 NM_023598 RefSeq (protein) NP_001231567 NP_115575 NP_076087 Location (UCSC) Chr 10: 61.9 – 62.1 Mb Chr 10: 67.93 – 68.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Alternative names for this gene include Modulator recognition factor 23.

Genomics

The gene is located on the long arm of chromosome 10 (10q21.2) on the 'plus' strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilodaltons respectively.

Clinical importance

Through genome wide association studies (GWAS), some of the single nucleotide polymorphisms (SNPs) located in this gene has been noticed to be significantly associated with susceptibility as well as treatment outcomes of childhood acute lymphoblastic leukaemia in ethnically diverse populations.

External links

• Human ARID5B genome location and ARID5B gene details page in the UCSC Genome Browser.

Further reading

• Yuan YC, Whitson RH, Liu Q, Itakura K, Chen Y (Nov 1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases". Nature Structural Biology. 5 (11): 959–64. doi:10.1038/2934. PMID 9808040. S2CID 10099806.
• Whitson RH, Huang T, Itakura K (May 1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts". Biochemical and Biophysical Research Communications. 258 (2): 326–31. doi:10.1006/bbrc.1999.0643. PMID 10329386.
• Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.