ARL4D

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.

ARL4D
Identifiers
Aliases	ARL4D, ARF4L, ARL6, ADP ribosylation factor like GTPase 4D
External IDs	OMIM: 600732; MGI: 1933155; HomoloGene: 1255; GeneCards: ARL4D; OMA:ARL4D - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 43,398,993 bp End 43,401,137 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 101,556,367 bp End 101,558,658 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx vena cava oocyte testicle parotid gland gingival epithelium right lobe of liver left lobe of thyroid gland nipple olfactory zone of nasal mucosa Top expressed in decidua gastrula neural layer of retina medial ganglionic eminence seminal vesicula left lobe of liver yolk sac retinal pigment epithelium myocardium of ventricle islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity Cellular component cytoplasm plasma membrane nucleolus intracellular anatomical structure membrane nucleus Biological process protein secretion intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 379 80981 Ensembl ENSG00000175906 ENSMUSG00000034936 UniProt P49703 Q99PE9 RefSeq (mRNA) NM_001661 NM_025404 RefSeq (protein) NP_001652 NP_079680 Location (UCSC) Chr 17: 43.4 – 43.4 Mb Chr 11: 101.56 – 101.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet–Biedl syndrome (BBS).

External links

• Human ARL4D genome location and ARL4D gene details page in the UCSC Genome Browser.
• Human ARL6 genome location and ARL6 gene details page in the UCSC Genome Browser.

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W (Oct 1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science.7545954. PMID 7545954.
• Harshman K, Bell R, Rosenthal J, Katcher H, Miki Y, Swenson J, Gholami Z, Frye C, Ding W, Dayananth P (Aug 1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Human Molecular Genetics. 4 (8): 1259–66. doi:10.1093/hmg/4.8.1259. PMID 7581362.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (Aug 1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal". FEBS Letters. 456 (3): 384–8. doi:10.1016/S0014-5793(99)00759-0. PMID 10462049. S2CID 84422541.
• Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP (Oct 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Letters. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
• Nonaka Y, Tsuda N, Shichijo S, Ito M, Maeda Y, Harada M, Kamura T, Shigemori M, Itoh K (Oct 2002). "Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors". Tissue Antigens. 60 (4): 319–27. doi:10.1034/j.1399-0039.2002.600406.x. PMID 12472661.
• Chiang AP, Nishimura D, Searby C, Elbedour K, Carmi R, Ferguson AL, Secrist J, Braun T, Casavant T, Stone EM, Sheffield VC (Sep 2004). "Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)". American Journal of Human Genetics. 75 (3): 475–84. doi:10.1086/423903. PMC 1182025. PMID 15258860.
• Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (Sep 2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nature Genetics. 36 (9): 989–93. doi:10.1038/ng1414. PMID 15314642.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hofmann I, Thompson A, Sanderson CM, Munro S (Apr 2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane". Current Biology. 17 (8): 711–6. Bibcode:2007CBio...17..711H. doi:10.1016/j.cub.2007.03.007. PMID 17398095. S2CID 1341183.