Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene.[5][6][7][8]

ARMCX3
Identifiers
AliasesARMCX3, ALEX3, GASP6, dJ545K15.2, armadillo repeat containing, X-linked 3, armadillo repeat containing X-linked 3
External IDsOMIM: 300364; MGI: 1918953; HomoloGene: 9588; GeneCards: ARMCX3; OMA:ARMCX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016607
NM_177947
NM_177948

NM_027870
NM_001358520
NM_001358521

RefSeq (protein)

NP_082146
NP_001345449
NP_001345450

Location (UCSC)Chr X: 101.62 – 101.63 MbChr X: 133.66 – 133.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102401Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049047Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas". Biochem Biophys Res Commun. 280 (1): 340–7. doi:10.1006/bbrc.2000.4125. PMID 11162520.
  6. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  7. ^ Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally Interacts with the Developmental Regulatory Factor Sox10". J Biol Chem. 284 (20): 13629–40. doi:10.1074/jbc.M901177200. PMC 2679464. PMID 19304657.
  8. ^ a b "Entrez Gene: ARMCX3 armadillo repeat containing, X-linked 3".
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Further reading

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