Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene .[ 5] [ 6] [ 7]
ARPC3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P9N , 1TYQ , 1U2V , 4JD2 , 3DXK , 3UKU , 3UKR , 2P9P , 2P9K , 2P9U , 3ULE , 3RSE , 2P9S , 2P9I , 4XF2 , 2P9L , 1K8K , 3DXM , 4XEI
Identifiers Aliases ARPC3 External IDs OMIM : 604225 ; MGI : 1928375 ; HomoloGene : 4178 ; GeneCards : ARPC3 ; OMA :ARPC3 - orthologs Wikidata
ARP2/3 complex ARPC3 (21 kDa) subunit crystal structure of arp2/3 complex with bound adp and calcium
Symbol P21-Arc Pfam PF04062 InterPro IPR007204
This gene encodes one of seven subunits of the Arp2/3 protein complex . The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000111229 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029465 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly" . J Cell Biol . 138 (2): 375–84. doi :10.1083/jcb.138.2.375 . PMC 2138188 PMID 9230079 . ^ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (Jan 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins" . Biochem J . 328 (1): 105–12. doi :10.1042/bj3280105 . PMC 1218893 PMID 9359840 . ^ a b "Entrez Gene: ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa" .
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