ASAHL

NAAA
Identifiers
Aliases	NAAA, ASAHL, PLT, N-acylethanolamine acid amidase
External IDs	OMIM: 607469; MGI: 1914361; HomoloGene: 8686; GeneCards: NAAA; OMA:NAAA - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	75,941,013 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,426,029 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; rectum; ; mucosa of transverse colon; ; spleen; ; mucosa of sigmoid colon; ; blood; ; lymph node; ; minor salivary glands; ; olfactory zone of nasal mucosa;
	Top expressed in
	choroidal fissure; ; tail of embryo; ; lip; ; yolk sac; ; Epithelium of choroid plexus; ; lumbar spinal ganglion; ; granulocyte; ; white adipose tissue; ; spleen; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; fatty acid amide hydrolase activity;
Cellular component	cytoplasm; lysosome; extracellular exosome; lysosomal lumen; presynapse; extrinsic component of membrane; membrane;
Biological process	lipid metabolism; neurotransmitter secretion; biological process; fatty acid metabolic process; N-acylethanolamine metabolic process; lipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27163
	67111
	ENSG00000138744
	ENSMUSG00000029413
	Q02083
	Q9D7V9
	NM_001042402; NM_014435; NM_001363719
	NM_001163687; NM_025972
	NP_001035861; NP_055250; NP_001350648
	NP_001157159; NP_080248
	Wikidata
View/Edit Human	View/Edit Mouse

N-acylethanolamine-hydrolyzing acid amidase is an enzyme that in humans is encoded by the NAAA gene.^[5]^[6]^[7]

Function

This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138744 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029413 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hong SB, Li CM, Rhee HJ, Park JH, He X, Levy B, Yoo OJ, Schuchman EH (Feb 2000). "Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein". Genomics. 62 (2): 232–41. doi:10.1006/geno.1999.5953. PMID 10610717.
^ Goodchild NL, Wilkinson DA, Mager DL (Dec 1992). "A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta". Gene. 121 (2): 287–94. doi:10.1016/0378-1119(92)90133-A. PMID 1446826.
^ ^a ^b "Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like".

External links

Human NAAA genome location and NAAA gene details page in the UCSC Genome Browser.

Schulze H, Schepers U, Sandhoff K (2008). "Overexpression and mass spectrometry analysis of mature human acid ceramidase". Biol. Chem. 388 (12): 1333–43. doi:10.1515/BC.2007.152. PMID 18020949. S2CID 12612022.
Zhao LY, Tsuboi K, Okamoto Y, et al. (2008). "Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism". Biochim. Biophys. Acta. 1771 (11): 1397–405. doi:10.1016/j.bbalip.2007.10.002. PMID 17980170.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Tsuboi K, Sun YX, Okamoto Y, et al. (2005). "Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase". J. Biol. Chem. 280 (12): 11082–92. doi:10.1074/jbc.M413473200. PMID 15655246.
Huang Y, Tanimukai H, Liu F, et al. (2005). "Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain". Eur. J. Neurosci. 20 (12): 3489–97. doi:10.1111/j.1460-9568.2004.03852.x. PMID 15610181. S2CID 11515970.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138744 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029413 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610717-5] Hong SB, Li CM, Rhee HJ, Park JH, He X, Levy B, Yoo OJ, Schuchman EH (Feb 2000). "Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein". Genomics. 62 (2): 232–41. doi:10.1006/geno.1999.5953. PMID 10610717.

[pmid1446826-6] Goodchild NL, Wilkinson DA, Mager DL (Dec 1992). "A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta". Gene. 121 (2): 287–94. doi:10.1016/0378-1119(92)90133-A. PMID 1446826.

[entrez-7] "Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like".

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[7]

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ASAHL

Contents

Function

References

External links

Further reading