ATBF1

Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.

ZFHX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DA1, 2DA2, 2DA3
Identifiers
Aliases	ZFHX3, ATBF1, ATBT, ZNF927, zinc finger homeobox 3
External IDs	OMIM: 104155; MGI: 99948; HomoloGene: 21366; GeneCards: ZFHX3; OMA:ZFHX3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.2-q22.3 Start 72,782,885 bp End 73,891,871 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 108,669,276 bp End 109,688,262 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein buccal mucosa cell synovial joint tendon of biceps brachii lateral nuclear group of thalamus pericardium urethra mucosa of paranasal sinus trigeminal ganglion spinal ganglia Top expressed in ascending aorta aortic valve external carotid artery lacrimal gland internal carotid artery tunica media of zone of aorta vestibular membrane of cochlear duct ciliary body superior cervical ganglion lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity zinc ion binding metal ion binding core promoter sequence-specific DNA binding protein binding nucleic acid binding enzyme binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear body transcription regulator complex nucleus nucleoplasm Biological process negative regulation of myoblast differentiation regulation of transcription, DNA-templated regulation of locomotor rhythm muscle organ development transcription by RNA polymerase II circadian regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated response to transforming growth factor beta negative regulation of transcription by RNA polymerase II brain development regulation of neuron differentiation positive regulation of cell adhesion positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 463 11906 Ensembl ENSG00000140836 ENSMUSG00000038872 UniProt Q15911 Q61329 RefSeq (mRNA) NM_001164766 NM_006885 NM_007496 RefSeq (protein) NP_001158238 NP_008816 n/a Location (UCSC) Chr 16: 72.78 – 73.89 Mb Chr 8: 108.67 – 109.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Yamada K, Miura Y, Scheidl T, et al. (1996). "Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1". Genomics. 29 (2): 552–3. doi:10.1006/geno.1995.9967. PMID 8666409.
• Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838. PMID 9171351.
• Kaspar P, Dvoráková M, Králová J, et al. (1999). "Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein". J. Biol. Chem. 274 (20): 14422–8. doi:10.1074/jbc.274.20.14422. PMID 10318867.
• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Kaushik N, Malaspina A, de Belleroche J (2000). "Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization". DNA Cell Biol. 19 (5): 265–73. doi:10.1089/10445490050021177. PMID 10855793.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Iida M, Imura J, Furuichi T, et al. (2004). "Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?". Oncol. Rep. 11 (1): 3–7. doi:10.3892/or.11.1.3. PMID 14654895.
• Nojiri S, Joh T, Miura Y, et al. (2004). "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3". Biochem. Biophys. Res. Commun. 314 (1): 97–103. doi:10.1016/j.bbrc.2003.12.054. PMID 14715251.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
• Zhang Z, Yamashita H, Toyama T, et al. (2005). "ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer". Clin. Cancer Res. 11 (1): 193–8. doi:10.1158/1078-0432.193.11.1. PMID 15671546.
• Sun X, Frierson HF, Chen C, et al. (2005). "Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer". Nat. Genet. 37 (4): 407–12. doi:10.1038/ng1528. PMID 15750593. S2CID 19458711.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Xu J, Sauvageot J, Ewing CM, et al. (2006). "Germline ATBF1 mutations and prostate cancer risk". Prostate. 66 (10): 1082–5. doi:10.1002/pros.20430. PMID 16637072. S2CID 21238472.
• Sun X, Zhou Y, Otto KB, et al. (2007). "Infrequent mutation of ATBF1 in human breast cancer". J. Cancer Res. Clin. Oncol. 133 (2): 103–5. doi:10.1007/s00432-006-0148-y. PMID 16932943. S2CID 12378418.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Mori Y, Kataoka H, Miura Y, et al. (2007). "Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer". Int. J. Cancer. 121 (2): 241–7. doi:10.1002/ijc.22654. PMID 17330845. S2CID 37176312.
• Cho YG, Song JH, Kim CJ, et al. (2007). "Genetic alterations of the ATBF1 gene in gastric cancer". Clin. Cancer Res. 13 (15 Pt 1): 4355–9. doi:10.1158/1078-0432.CCR-07-0619. PMID 17671116.

External links

• ATBF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ZFHX3 genome location and ZFHX3 gene details page in the UCSC Genome Browser.