ATP5G1

The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

ATP5MC1
Identifiers
Aliases	ATP5MC1, ATP5A, ATP5G, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9), ATP synthase membrane subunit c locus 1, ATP5G1
External IDs	OMIM: 603192; MGI: 107653; HomoloGene: 38017; GeneCards: ATP5MC1; OMA:ATP5MC1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 48,892,765 bp End 48,895,871 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 95,959,678 bp End 95,966,496 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon right auricle rectum left ventricle muscle of thigh gastrocnemius muscle body of stomach right frontal lobe prefrontal cortex Top expressed in right kidney muscle of thigh blastocyst morula lip superior frontal gyrus yolk sac primary visual cortex dentate gyrus of hippocampal formation granule cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding transporter activity proton transmembrane transporter activity protein binding proton-transporting ATP synthase activity, rotational mechanism Cellular component proton-transporting ATP synthase complex, coupling factor F(o) membrane integral component of membrane mitochondrion mitochondrial membranes proton-transporting two-sector ATPase complex, proton-transporting domain mitochondrial proton-transporting ATP synthase complex mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial inner membrane Biological process ion transport ATP biosynthetic process ATP synthesis coupled proton transport cristae formation mitochondrial ATP synthesis coupled proton transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 516 11951 Ensembl ENSG00000159199 ENSMUSG00000006057 UniProt P05496 Q9CR84 RefSeq (mRNA) NM_005175 NM_001002027 NM_001161419 NM_007506 RefSeq (protein) NP_001002027 NP_005166 NP_001154891 NP_031532 Location (UCSC) Chr 17: 48.89 – 48.9 Mb Chr 11: 95.96 – 95.97 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.

External links

• Human ATP5MC1 genome location and ATP5MC1 gene details page in the UCSC Genome Browser.

Further reading

• Farrell LB, Nagley P (May 1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex". Biochemical and Biophysical Research Communications. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
• Yan WL, Lerner TJ, Haines JL, Gusella JF (Nov 1994). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
• Higuti T, Kawamura Y, Kuroiwa K, Miyazaki S, Tsujita H (Apr 1993). "Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1173 (1): 87–90. doi:10.1016/0167-4781(93)90249-D. PMID 8485160.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Elston T, Wang H, Oster G (Jan 1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
• Wang H, Oster G (Nov 1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Cross RL (Jan 2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816. S2CID 52819856.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Wang HL, Zhu ZM, Yerle M, Wu X, Wang H, Yang SL, Li K (2005). "Full-length coding sequences and mapping of porcine ATP6VOE and ATP5G1 genes". Cytogenetic and Genome Research. 109 (4): 533. doi:10.1159/000084223. PMID 15906478.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.