Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene.[5][6][7] In contrast to initial suggestions,[5] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells [8][9]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000142920 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028789 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications. 287 (5): 1051–1057. doi:10.1006/bbrc.2001.5703. PMID 11587527.
- ^ Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochimica et Biophysica Acta (BBA) - General Subjects. 1670 (2): 156–164. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
- ^ "Entrez Gene: ADC arginine decarboxylase".
- ^ Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.
- ^ López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.
Further reading
edit- Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–327. doi:10.1093/dnares/8.6.319. PMID 11853319.
- Coleman CS, Hu G, Pegg AE (May 2004). "Putrescine biosynthesis in mammalian tissues". The Biochemical Journal. 379 (Pt 3): 849–855. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
- Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (March 2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochemical and Biophysical Research Communications. 328 (1): 206–212. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
- López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.
- Tian H, Liu X, Zhang B, Sun Q, Sun D (June 2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochimica et Biophysica Sinica. 39 (6): 423–430. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
- Levin VA, Jochec JL, Shantz LM, Aldape KD (November 2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". International Journal of Cancer. 121 (10): 2279–2283. doi:10.1002/ijc.22914. PMID 17582600.
- Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.
External links
edit- Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.
- Human AZIN2 genome location and AZIN2 gene details page in the UCSC Genome Browser.
 | This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |