A Change of Heart may refer to:
- "A Change of Heart" (How I Met Your Mother), an episode of the TV series How I Met Your Mother
- A Change of Heart (TV series), a Hong Kong television series
- A Change of Heart (album), a 1987 album by David Sanborn
- "A Change of Heart" (Bernard Butler song), 1998
- "A Change of Heart" (The 1975 song), 2016
- A Father for Brittany (also known as A Change of Heart), a 1998 Lifetime television film
- A Change of Heart, a 1998 TV movie starring Jean Smart
- A Change of Heart (film), a 2017 comedy film starring Jim Belushi