Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing.[1]
| Accelerated phase chronic myelogenous leukemia | |
|---|---|
| Specialty | Hematology and oncology |
Symptoms
editCommon symptoms include fever, bone pain, and swollen spleen.[2]
Treatment
editPatients treated with imatinib, dasatinib, and nilotinib have shown meaningful rates of hematologic and cytogenetic response.[3]
Prognosis
editPrognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase; it behaves similarly to acute myeloid leukemia.
References
edit- ^ Moshe Talpaz (2002). "Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study". Blood. 99 (6): 1928–1937. doi:10.1182/blood.v99.6.1928. PMID 11877262. S2CID 29480569.
- ^ "Chronic myelogenous leukemia (CML)".
- ^ Shah, NP (Mar 2008). "Advanced CML: therapeutic options for patients in accelerated and blast phases". Journal of the National Comprehensive Cancer Network. 6 Suppl 2: S31–S36. PMID 18397679.
External links
edit- Accelerated phase chronic myelogenous leukemia entry in the public domain NCI Cancer Dictionary
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