Aceclidine (Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma.
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Topical (ophthalmic solution) |
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| Metabolism | deacetylation? |
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| ECHA InfoCard | 100.011.431 |
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| Formula | C9H15NO2 |
| Molar mass | 169.224 g·mol−1 |
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Medicinal properties
editAceclidine decreases intraocular pressure. It acts as a muscarinic acetylcholine receptor agonist.[1]
Side effects of aceclidine include increased salivation and bradycardia (in excessive doses).
Chemistry
editAceclidine is an organic compound that is structurally related to quinuclidine. As such its alternative name is 3-acetoxyquinuclidine. Its protonated derivative has a pKa of 9.3.[2]
See also
edit- Talsaclidine (drug with a similar structure)
- Muscarine
- List of Russian drugs
References
edit- ^ Shannon HE, Hart JC, Bymaster FP, Calligaro DO, DeLapp NW, Mitch CH, et al. (August 1999). "Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats". The Journal of Pharmacology and Experimental Therapeutics. 290 (2): 901–907. PMID 10411607.
- ^ Aggarwal VK, Emme I, Fulford SY (February 2003). "Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope". The Journal of Organic Chemistry. 68 (3): 692–700. doi:10.1021/jo026671s. PMID 12558387.