In enzymology, an acetone carboxylase (EC 6.4.1.6) is an enzyme that catalyzes the chemical reaction
Acetone carboxylase | |||||||||
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Identifiers | |||||||||
EC no. | 6.4.1.6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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- acetone + CO2 + ATP + 2 H2O acetoacetate + AMP + 2 phosphate
The 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is acetone:carbon-dioxide ligase (AMP-forming).
References
edit- Sluis MK, Ensign SA (1997). "Purification and characterization of acetone carboxylase from Xanthobacter strain Py2". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8456–61. doi:10.1073/pnas.94.16.8456. PMC 22955. PMID 9237998.