Acetylsalicylate deacetylase

The enzyme acetylsalicylate deacetylase (EC 3.1.1.55) catalyzes the reaction

acetylsalicylate deacetylase
Identifiers
EC no.3.1.1.55
CAS no.87348-04-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
acetylsalicylate + H2O salicylate + acetate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is acetylsalicylate O-acetylhydrolase. Other names in common use include aspirin esterase, acetylsalicylic acid esterase, and aspirin hydrolase.

References

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  • Ali B, Kaur S (1983). "Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases". J. Pharmacol. Exp. Ther. 226 (2): 589–94. PMID 6875867.
  • Kim DH, Yang YS, Jakoby WB (1990). "Aspirin hydrolyzing esterases from rat liver cytosol". Biochem. Pharmacol. 40 (3): 481–7. doi:10.1016/0006-2952(90)90546-W. PMID 2383281.
  • White KN, Hope DB (1984). "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver". Biochim. Biophys. Acta. 785 (3): 138–47. doi:10.1016/0167-4838(84)90138-9. PMID 6704404.