Acid—CoA ligase (GDP-forming)

In enzymology, an acid—CoA ligase (GDP-forming) (EC 6.2.1.10) is an enzyme that catalyzes the chemical reaction

Acid—CoA ligase (GDP-forming)
Identifiers
EC no.6.2.1.10
CAS no.37318-59-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
GTP + an acid + CoA GDP + phosphate + acyl-CoA

The 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acid:CoA ligase (GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming).

References

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  • Rossi CR, Gibson DM (June 1964). "Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria" (PDF). The Journal of Biological Chemistry. 239 (6): 1694–9. PMID 14213337.