Acquah is a Fante surname. Notable people with this surname include:
- Afriyie Acquah (born 1992), Ghanaian footballer
- Edward Acquah (1935–2011), Ghanaian footballer
- George Kingsley Acquah (1942–2007), Ghanaian lawyer and chief justice
- Henry Acquah (born 1965), Ghanaian footballer
- Milan Acquaah (born 1997), American basketball player
- Paul Amoako Acquah, a Ghanaian economist and a former deputy director for the Africa Department of the International Monetary Fund from 1998 to 2001.[1] He is also a former Governor of the Bank of Ghana (2001-2009).
- Raymond Acquah (born 1988) Ghanaian Journalist, Documentarian and Fact-Checker