Acrosin binding protein is a protein that in humans is encoded by the ACRBP gene. [5]
| ACRBP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ACRBP, CT23, OY-TES-1, SP32, acrosin binding protein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608352; MGI: 1859515; HomoloGene: 9641; GeneCards: ACRBP; OMA:ACRBP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
editThe protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon.
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000111644 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072770 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Acrosin binding protein". Retrieved 2016-08-01.
Further reading
edit- Okumura H, Noguchi Y, Uenaka A, Aji T, Ono T, Nakagawa K, Aoe M, Shimizu N, Nakayama E (2005). "Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells". Microbiol. Immunol. 49 (11): 1009–16. doi:10.1111/j.1348-0421.2005.tb03688.x. PMID 16301813. S2CID 24003855.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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