Actin related protein 2/3 complex inhibitor

Actin related protein 2/3 complex inhibitor is a protein that in humans is encoded by the ARPIN gene.

ARPIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z68
Identifiers
Aliases	ARPIN, C15orf38, actin-related protein 2/3 complex inhibitor, actin related protein 2/3 complex inhibitor
External IDs	OMIM: 615543; MGI: 1917670; HomoloGene: 128480; GeneCards: ARPIN; OMA:ARPIN - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.1 Start 89,895,006 bp End 89,912,952 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D2 Start 79,575,109 bp End 79,585,107 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas corpus epididymis mucosa of sigmoid colon epithelium of colon synovial joint seminal vesicula urethra right ventricle caput epididymis nipple Top expressed in external carotid artery internal carotid artery endothelial cell of lymphatic vessel otolith organ duodenum utricle jejunum ileum migratory enteric neural crest cell yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cell projection lamellipodium Biological process negative regulation of lamellipodium morphogenesis directional locomotion negative regulation of cell migration negative regulation of actin nucleation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 348110 70420 Ensembl ENSG00000242498 ENSMUSG00000039043 UniProt Q7Z6K5 Q9D0A3 RefSeq (mRNA) NM_182616 NM_001282380 NM_027420 RefSeq (protein) NP_001269309 NP_872422 NP_081696 Location (UCSC) Chr 15: 89.9 – 89.91 Mb Chr 7: 79.58 – 79.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Deng WS, Zhang J, Ju H, Zheng HM, Wang J, Wang S, Zhang DL (2015). "Arpin contributes to bacterial translocation and development of severe acute pancreatitis". World J. Gastroenterol. 21 (14): 4293–301. doi:10.3748/wjg.v21.i14.4293. PMC 4394092. PMID 25892881.
• Liu X, Zhao B, Wang H, Wang Y, Niu M, Sun M, Zhao Y, Yao R, Qu Z (2016). "Aberrant expression of Arpin in human breast cancer and its clinical significance". J. Cell. Mol. Med. 20 (3): 450–8. doi:10.1111/jcmm.12740. PMC 4759471. PMID 26648569.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Actin related protein 2/3 complex inhibitor (ARPIN)