Adenoma sebaceum, also known as facial angiofibroma is a misnamed cutaneous disorder consisting of angiofibromas that begin in childhood (generally present between 2–5 years of age) and appear clinically as red papules on the face especially on the nasolabial folds, cheek and chin,[1]: 195 often misidentified as acne not responding to treatment. Adenoma sebaceum may at times be associated with tuberous sclerosis.[2] Gradually the papules become more prominent with time and persist throughout life.[3] Cosmetic removal by argon or pulse dye laser or scalpel is indicated.
| Adenoma sebaceum | |
|---|---|
| Other names | Facial angiofibroma |
,_early_twentieth_century_(23966574919).jpg) | |
| Wax moulage, side view of a child's face showing 'adenoma sebaceum' (a genetic skin disorder), early twentieth century | |
| Specialty | Dermatology |
Signs and symptoms
editAdenoma sebaceum are several tiny, pinkish, erythematous hamartomas that cover the nose and cheeks in a distinctive butterfly pattern during early childhood or infancy.[4][5] They typically occur in the nasolabial folds and are symmetrical.[6]
Diagnosis
editAdenoma sebaceum presence represents one of the major diagnostic criteria to confirm the diagnosis of tuberous sclerosis.[5] When adenoma sebaceum presents with seizures and mental retardation (Vogt's triad), it indicates that cranial imaging is necessary, other differential diagnoses for this disorder include acne vulgaris, rhinophyma, and sebaceous hyperplasia.[5][7]
Treatment
editAdenoma sebaceum can be eliminated with dermabrasion or a laser.[8]
See also
editReferences
edit- ^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. ISBN 1-4160-3185-5.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
- ^ "DermIS — Adenoma Sebaceum (information on the diagnosis)". www.dermis.net. Retrieved 2016-01-01.
- ^ Boggarapu, Sreedevi; Roberds, Steven L.; Nakagawa, JoAnne; Beresford, Eric (2022-09-14). "Characterization and management of facial angiofibroma related to tuberous sclerosis complex in the United States: retrospective analysis of the natural history database". Orphanet Journal of Rare Diseases. 17 (1). Springer Science and Business Media LLC. doi:10.1186/s13023-022-02496-2. ISSN 1750-1172. PMC 9476292. PMID 36104799.
- ^ a b c Goodrick, Steven (2015). "The road to Vogt's triad". The Lancet Neurology. 14 (7). Elsevier BV: 690. doi:10.1016/s1474-4422(15)00108-8. ISSN 1474-4422. PMID 26067122.
- ^ Osborne, J P (1988-12-01). "Diagnosis of tuberous sclerosis". Archives of Disease in Childhood. 63 (12). BMJ: 1423–1425. doi:10.1136/adc.63.12.1423. ISSN 0003-9888. PMC 1779182. PMID 3069050.
- ^ Hemady, Nikhil; Ohri, Sameer (2009-01-01). "Papulonodular lesions in a man with seizures and mental retardation. Adenoma sebaceum". American Family Physician. 79 (1): 48, 51. ISSN 0002-838X. PMID 19145966.
- ^ Schwartsmann, G.; Peters, G. J.; Laurensse, E.; de Waal, F. C.; Loonen, A. H.; Leyva, A.; Pinedo, H. M. (1988-09-01). "DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects". Biochemical Pharmacology. 37 (17): 3257–3266. doi:10.1016/0006-2952(88)90636-3. ISSN 0006-2952. PMID 2840910.
Further reading
edit- Krishnan, Prasad; Patel, SachinkumarMaheshbhai (2016). "Adenoma sebaceum: Dermatological finding unmasking central nervous system pathology". Journal of Pediatric Neurosciences. 11 (4). Medknow: 378. doi:10.4103/1817-1745.199465. ISSN 1817-1745. PMC 5314862. PMID 28217171.
- Cruess, Alan F.; Sharma, Sanjay (2006). "Tuberous Sclerosis and the Eye". Retina. Elsevier. doi:10.1016/b978-0-323-02598-0.50031-8. ISBN 978-0-323-02598-0.