Adenosylmethionine hydrolase

In enzymology, an adenosylmethionine hydrolase (EC 3.3.1.2) is an enzyme that catalyzes the chemical reaction

adenosylmethionine hydrolase
Identifiers
EC no.3.3.1.2
CAS no.37288-62-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
S-adenosyl-L-methionine + H2O L-homoserine + methylthioadenosine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and H2O, whereas its two products are L-homoserine and methylthioadenosine.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds involving sulfur (thioether and trialkylsulfonium hydrolases). The systematic name of this enzyme class is S-adenosyl-L-methionine hydrolase. Other names in common use include S-adenosylmethionine cleaving enzyme, methylmethionine-sulfonium-salt hydrolase, and adenosylmethionine lyase.

References

edit
  • Mazelis M, Levin B, Mallinson N (1965). "Decomposition of methyl methionine sulfonium salts by a bacterial enzyme". Biochim. Biophys. Acta. 105 (1): 106–14. doi:10.1016/s0926-6593(65)80179-5. PMID 5849106.