Ae binding protein 1

AE binding protein 1 is a protein that in humans is encoded by the AEBP1 gene.

AEBP1
Identifiers
Aliases	AEBP1, ACLP, AE binding protein 1
External IDs	OMIM: 602981; MGI: 1197012; HomoloGene: 878; GeneCards: AEBP1; OMA:AEBP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p13 Start 44,104,345 bp End 44,114,562 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A1 Start 5,811,947 bp End 5,822,088 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii thoracic aorta ascending aorta right coronary artery Descending thoracic aorta popliteal artery tibial arteries left coronary artery saphenous vein canal of the cervix Top expressed in ascending aorta aortic valve calvaria tunica media of zone of aorta uterus cervix body of femur adrenal gland stroma of bone marrow tunica adventitia of aorta More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity zinc ion binding calmodulin binding DNA-binding transcription repressor activity, RNA polymerase II-specific metallocarboxypeptidase activity carboxypeptidase activity serine-type carboxypeptidase activity extracellular matrix structural constituent collagen binding Cellular component cytoplasm extracellular matrix extracellular exosome nucleus extracellular space extracellular region collagen-containing extracellular matrix Biological process skeletal system development regulation of transcription, DNA-templated peptide metabolic process protein processing muscle organ development negative regulation of transcription by RNA polymerase II transcription, DNA-templated proteolysis regulation of collagen fibril organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 165 11568 Ensembl ENSG00000106624 ENSMUSG00000020473 UniProt Q8IUX7 Q640N1 RefSeq (mRNA) NM_001129 NM_001291857 NM_009636 RefSeq (protein) NP_001120 NP_001278786 NP_033766 Location (UCSC) Chr 7: 44.1 – 44.11 Mb Chr 11: 5.81 – 5.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

AE binding protein 1 is a member of carboxypeptidase A protein family. The protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that the AEBP1 gene that encodes the protein functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma.

External links

• Human AEBP1 genome location and AEBP1 gene details page in the UCSC Genome Browser.

Further reading

• Tumelty KE, Smith BD, Nugent MA, Layne MD (2014). "Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent and -independent pathways". Journal of Biological Chemistry. 289 (5): 2526–36. doi:10.1074/jbc.M113.502617. PMC 3908388. PMID 24344132.
• Lyons PJ, Muise AM, Ro HS (2005). "MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1". Biochemistry. 44 (3): 926–31. doi:10.1021/bi0480178. PMID 15654748.
• Majdalawieh A, Ro HS (2010). "PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1". Nuclear Receptor Signaling. 8: e004. doi:10.1621/nrs.08004. PMC 2858268. PMID 20419060.
• Muise AM, Ro HS (1999). "Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: Stimulation of enzymic activity by its target DNA". The Biochemical Journal. 343 (2): 341–5. doi:10.1042/0264-6021:3430341. PMC 1220559. PMID 10510298.
• Feldkamp ML, Bowles NE, Botto LD (2012). "AEBP1 gene variants in infants with gastroschisis". Birth Defects Research Part A: Clinical and Molecular Teratology. 94 (9): 738–42. doi:10.1002/bdra.23041. PMID 22821744.
• Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME (2001). "Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein". Molecular and Cellular Biology. 21 (15): 5256–61. doi:10.1128/MCB.21.15.5256-5261.2001. PMC 87249. PMID 11438679.
• Ohno I, Hashimoto J, Shimizu K, Takaoka K, Ochi T, Matsubara K, Okubo K (1996). "A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line". Biochemical and Biophysical Research Communications. 228 (2): 411–4. doi:10.1006/bbrc.1996.1675. PMID 8920928.
• Majdalawieh A, Ro HS (2010). "Regulation of Ikappa Balpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages". Mediators of Inflammation. 2010: 823821. doi:10.1155/2010/823821. PMC 2855089. PMID 20396415.
• Song L, Fricker LD (1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". The Journal of Biological Chemistry. 272 (16): 10543–50. doi:10.1074/jbc.272.16.10543. PMID 9099699.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.