af Uglas is a Swedish family name, meaning "of Owls". It can refer to:
- Bertil af Ugglas (1934–1977), Swedish politician and elected official
- Caroline af Ugglas (born 1972), Swedish singer, artist and chorister
- Ludvig af Ugglas (1814–1880), Swedish politician and member of the upper house of the Parliament of Sweden
- Margaretha af Ugglas (born 1939), Swedish former Moderate Party politician and Minister for Foreign Affairs