Afamin

Afamin is a protein that in humans is encoded by the AFM gene.

AFM
Identifiers
Aliases	AFM, ALB2, ALBA, ALF, afamin
External IDs	OMIM: 104145; MGI: 2429409; HomoloGene: 881; GeneCards: AFM; OMA:AFM - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.3 Start 73,481,745 bp End 73,504,001 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E1 Start 90,666,791 bp End 90,701,402 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle kidney tubule human kidney glomerulus metanephric glomerulus tibialis anterior muscle renal medulla mucosa of ileum fundus Top expressed in left lobe of liver human kidney right kidney proximal straight tubule renal pelvis fetal liver hematopoietic progenitor cell renal calyx sexually immature organism migratory enteric neural crest cell gallbladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vitamin E binding protein binding Cellular component extracellular region blood microparticle extracellular exosome extracellular space Biological process vitamin transport transport protein transport protein stabilization protein transport within extracellular region Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 173 280662 Ensembl ENSG00000079557 ENSMUSG00000029369 UniProt P43652 O89020 RefSeq (mRNA) NM_001133 NM_145146 RefSeq (protein) NP_001124 NP_660128 Location (UCSC) Chr 4: 73.48 – 73.5 Mb Chr 5: 90.67 – 90.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.

External links

• Human AFM genome location and AFM gene details page in the UCSC Genome Browser.

Further reading

• Noppe M, Lowenthal A, Karcher D, Gheuens J (1979). "A two-site immunoradiometric assay for the determination of alpha-albumin". J. Immunol. Methods. 27 (1): 75–81. doi:10.1016/0022-1759(79)90240-0. PMID 37276.
• Hansson E, Rönnbäck L, Lowenthal A, Noppe M (1985). "Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis". Brain Res. 353 (2): 175–85. doi:10.1016/0165-3806(85)90206-8. PMID 4041902.
• Lowenthal A, Flament-Durand J, Karcher D, Noppe M, Brion JP (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland". J. Neurochem. 38 (3): 863–5. doi:10.1111/j.1471-4159.1982.tb08714.x. PMID 7035619. S2CID 40660858.
• Allard D, Gilbert S, Lamontagne A, Hamel D, Bélanger L (1995). "Identification of rat alpha-albumin and cDNA cloning of its human ortholog". Gene. 153 (2): 287–8. doi:10.1016/0378-1119(94)00745-E. PMID 7875606.
• Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A (1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription". J. Mol. Biol. 259 (1): 113–9. doi:10.1006/jmbi.1996.0306. PMID 8648639.
• Nishio H, Dugaiczyk A (1996). "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7557–61. Bibcode:1996PNAS...93.7557N. doi:10.1073/pnas.93.15.7557. PMC 38784. PMID 8755513.
• Song YH, Naumova AK, Liebhaber SA, Cooke NE (1999). "Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster". Genome Res. 9 (6): 581–7. doi:10.1101/gr.9.6.581. PMC 310762. PMID 10400926.
• Khan MA, Kumar Y, Tayyab S (2003). "Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin". Int. J. Biol. Macromol. 30 (3–4): 171–8. doi:10.1016/S0141-8130(02)00017-X. PMID 12063119.
• Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H (2003). "Characterization of the vitamin E-binding properties of human plasma afamin". Biochemistry. 41 (49): 14532–8. doi:10.1021/bi026513v. PMID 12463752.
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.
• Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H (2005). "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression". J. Proteome Res. 4 (3): 889–99. CiteSeerX 10.1.1.706.313. doi:10.1021/pr0500105. PMID 15952736.
• Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid". Mol. Cell. Proteomics. 4 (12): 2000–9. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.