Aganodine

Aganodine
Names
	IUPAC name 2-(4,7-Dichloro-1,3-dihydroisoindol-2-yl)guanidine
Identifiers
CAS Number	86696-87-9;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2105912;
ChemSpider	154051;
PubChem CID	176878;
UNII	670P9AQR46;
CompTox Dashboard (EPA)	DTXSID60235775 ;
	InChI InChI=1S/C9H10Cl2N4/c10-7-1-2-8(11)6-4-15(3-5(6)7)14-9(12)13/h1-2H,3-4H2,(H4,12,13,14) Key: DFKHOVYSCCPSHR-UHFFFAOYSA-N;
	SMILES C1C2=C(C=CC(=C2CN1N=C(N)N)Cl)Cl;
Properties
Chemical formula	C9H10Cl2N4
Molar mass	245.109
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Aganodine is a guanidine that activates presynaptic imidazoline receptors.^[1] Through its agonism at imidazoline receptors, aganodine inhibits the presynaptic release of norepinephrine.^[2]

References

^ Molderings, GJ; Likungu, J; Jakschik, J; Göthert, M (1997). "Presynaptic imidazoline receptors and non-adrenoceptor 3H-idazoxan binding sites in human cardiovascular tissues". British Journal of Pharmacology. 122 (1): 43–50. doi:10.1038/sj.bjp.0701343. PMC 1564902. PMID 9298527.
^ Göthert, M.; Brüss, M.; Bönisch, H.; Molderings, G.J. (1999). "Presynaptic Imidazoline Receptors". Annals of the New York Academy of Sciences. 881: 171–184. doi:10.1111/j.1749-6632.1999.tb09356.x. PMID 10415912. S2CID 12242403.

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