Akhundzade is an Azerbaijani surname. Notable people with the surname include:
- Mirza Abu Turab Akhundzade (1817–1910), Azerbaijani theologian and educator
- Mirza Fatali Akhundzade (1812-1878), Iranian Azerbaijani author and philosopher
- Nariman Akhundzade (born 2004), Azerbaijani footballer
- Yusif Akhundzade, Azerbaijani military conductor and director
- Shukriyya Akhundzade, wife of the Azerbaijani poet Ahmad Javad and a victim of the Stalinist repressions in Azerbaijan.